The first real weapon you get, the pistol is the classic gun in Doom 3. Comparatively weak but also very accurate. The design is similar to the Pistol featured in the classic Doom games, but more of the weapon is visible. In Doom 3, the pistol is considerably more powerful, but often seems weaker, due to the fact that several of the weaker monsters have been "beefed up" compared to their classic counterparts.
It is best used to conserve ammo or as a backup weapon for when stronger weapons get close to emptying their magazines. In mid and close range, the machine gun is far more powerful, but the pistol is very accurate, so use it for enemies at long distance, or when you run out of ammo. It is also a worthy weapon against Trites, being able to kill one with two bullets, and against Lost Souls if your aim is reliable. But when they come closer, swap to something more powerful.
- The appearance of the pistol is influenced by the pistol that Harrison Ford's character Rick Deckard carries in the Blade Runner film.
- The pistol (with no sound mods) uses the same sound as Half-Life: Opposing Force's Desert Eagle.