After being tasked by the Maledict to hunt the Artifact, the Helltime Hunter is the first enemy who confronts the marine and is encountered in front of a hell portal near the excavations. As this Hunter appears the Maledict says that the marine has met his death, so he is quite convinced that the Hunter can cope with the soldier. In order to defeat the Helltime Hunter, the player must use the Grabber to catch the plasma balls that are launched from the Martian defense turrets and send them back to the Hunter himself. It can be difficult at times, since the Hunter can move from certain places of the area instantly. It takes about 4-5 direct plasma ball hits on the Hunter to kill him.
After the player kills the Helltime Hunter, the Artifact becomes usable, since it now has the Helltime ability. From then on, the player can use the Artifact to slow time down. It does not affect the player's movement or weapons in any way. The Helltime Hunter is the only boss who cannot be defeated by weapons other than the Grabber, even if the player uses a stronger weapon procured by using cheats.